Native Proteins and Derivatives
Cayman Chemical CalpaIn InhIbItr I 5mg
A bioactive saponin from traditional Chinese medicine dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 23 UM LC50 865 UM) has diverse protective effects for the cardiovascular immune digestive and nervous systems reduces myocardial infarct size in dogs
Cayman Chemical CalpaIn InhIbItr XII 1mg
A MRN complex inhibitor inhibits DSB-induced H2AX phosphorylation (IC50 66 UM in X. laevis cell-free extracts) inhibits the exonuclease activity of Mre11 in a cell-free assay at 100 UM induces cell cycle arrest at the G2 phase in TOSA4 cells and inhibits homology-dependent repair in HEK293 cells in a concentration-dependent manner reduces tumor growth in an LA-N-5 mouse xenograft model when encapsulated in nanoparticles at 50 mg/kg
Cayman Chemical CalpaIn InhIbItr II 25mg
A potent PLD2 inhibitor both in vitro (IC50 140 nM) and in cells (IC50 110 nM) also effective as a PLD1 inhibitor at higher concentrations (IC50 5.1 M in vitro 1.0 M in cells) strongly inhibits the invasive migration of breast cancer cells in transwell assays
Sigma Aldrich Fine Chemicals Biosciences fibronectin bovine plasma5MG
fibronectin is a glycoprotein with multiple domains. It comprises a N-terminal central binding domain and a heparin-binding domain. Bovine plasma fibronectin has polypeptide chains with disulfide linkage and corresponds to a molecular weight of 220 and 215 kDa.
Cayman Chemical CalpaIn InhIbItr II 5mg
An inhibitor of c-Kit (IC50 200 nM) an inhibitor of PDGFRa PDGFRB and Lyn B (IC50s 540 800 and 510 nM respectively) inhibits stem cell factor-induced proliferation of Ba/F3 cells expressing wild-type KIT (IC50 150 nM) as well as those expressing the KIT mutants KITV559D and KIT27 (IC50s 3 and 5 nM respectively) an inhibitor of SARS-CoV-2 Mpro (Ki 2.6 UM) inhibits replication of SARS-CoV-2 in infected A549 cells (EC50 3.2 UM) decreases lung and nose viral titers as well as reduces lung inflammation and increases survival in ACE2-humanized mice infected with SARS-CoV-2 at 25 mg/kg
Cayman Chemical CalpaIn InhIbItr III 10mg
A triacylglycerol containing heneicosaNIc acid groups at the sn-1 sn-2 and sn-3 positions has been used as an internal standard for the quantification of fatty acids in human breast milk samples and triacylglycerols in rat heart
Cayman Chemical 3AmIno3deoxyadenosIn5 2.1mg
An agonist of PPARa activates PPARa in HepG2 cells in a reporter assay at 1 UM but does not activate PPARB or PPARY at 10 UM prevents T0901317-induced triglyceride accumulation in HepG2 cells at 3 UM scavenges ROS and peroxynitrite in cell-free assays (IC50s 39.7 and 2.39 UM respectively) inhibitsBglucuronidase and tyrosinase (IC50s 8.9 and 0.01 UM for the bovine liver and mushroom enzymes respectively) reduces age-induced increases in liver weight and triglyceride levels in a rat model of hepatic steatosis at 5 mg/kg
Cayman Chemical 3OMethylgunosIn5OtrI 2.7mg
A lignan scavenges ABTS radicals in a cell-free assay (IC50 19.4 UM) inhibits LPS-induced NO production in RAW 264.7 macrophages (IC50 84.45 UM) inhibits AB42 self-aggregation in a cell-free assay at 20 UM
Cayman Chemical Rp2DeoxyadenosIn5O 1 2.1mg
An ETA receptor antagonist (Ki 13 nM in rat aortic vascular smooth muscle cells) inhibits ET-1-induced contractions in isolated rat aortic rings and mesenteric microvessels (pA2s 8.1 and 7.97 respectively) decreases systolic blood pressure in DOCA-salt hypertensive rats at 50 mg/kg decreases MAP and LVDP in normotensive pigs at 1 and 5 mg/kg reduces myocardial infarct size as a percentage of the area at risk in a porcine model of LAD coronary artery ligation-induced ischemia-reperfusion injury
Cayman Chemical Nat-20 S-yn 25mg
A TLR3 TLR8 and TLR9 receptor agonist selectively induces NF-KB activation in HEK293 cells expressing recombinant human TLR3 TLR8 or TLR9 (EC50s 4.8 13.45 and 5.66 UM respectively) over HEK293 cells expressing recombinant human TLR2 TLR4 TLR5 or TLR7 (EC50s >100 UM for all) induces TNF-a IL-6 and IL-8 production in THP-1 cells from 5-40 UM inhibits the growth of HeLa cells (IC50 2.71 UM)
Sigma Aldrich Fine Chemicals Biosciences Lipoprotein Lipase from Ps50MG
Lipoprotein Lipase (LPL) is majorly secreted by myocytes and adipocytes in humans and is crucial for triglyceride homeostatis. Mutations in the catalytic domain of LPL impairs its interaction with glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (GPIHBP1). The N-terminal catalytic domain is essential for lipolysis. The C-terminal is crucial for binding lipoproteins. Altered LPL levels may play role in the pathogenesis of atherosclerosis coronary heart disease and chronic lymphocytic leukemia.
Sigma Aldrich Fine Chemicals Biosciences Lipoprotein Lipase from Bu50MG
Lipoprotein lipase hydrolyzes triglycerides in plasma lipoproteins causing release of fatty acids for metabolic purposes in muscles and adipose tissue.